Human FGF2 activation kit by CRISPRa

CAT#: GA101570

FGF2 CRISPRa kit - CRISPR gene activation of human fibroblast growth factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGF2
• Locus ID: 2247
• Kit Components:

  GA101570G1, FGF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101570G2, FGF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101570G3, FGF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002006, NM_001361665
• Synonyms: BFGF; FGF-2; FGFB; HBGF-2
• Summary: 'The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]'