Human FKBP51 (FKBP5) activation kit by CRISPRa

CAT#: GA101602

FKBP5 CRISPRa kit - CRISPR gene activation of human FKBP prolyl isomerase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FKBP5
• Locus ID: 2289
• Kit Components:

  GA101602G1, FKBP51 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101602G2, FKBP51 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101602G3, FKBP51 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145775, NM_001145776, NM_001145777, NM_004117
• Synonyms: AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
• Summary: 'The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]'