Human Fibromodulin (FMOD) activation kit by CRISPRa

CAT#: GA101638

FMOD CRISPRa kit - CRISPR gene activation of human fibromodulin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FMOD
• Locus ID: 2331
• Kit Components:

  GA101638G1, Fibromodulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101638G2, Fibromodulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101638G3, Fibromodulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002023, NR_103757
• Synonyms: FM; SLRR2E
• Summary: 'Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]'