Human GCHFR activation kit by CRISPRa

CAT#: GA101763

GCHFR CRISPRa kit - CRISPR gene activation of human GTP cyclohydrolase I feedback regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GCHFR
• Locus ID: 2644
• Kit Components:

  GA101763G1, GCHFR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101763G2, GCHFR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101763G3, GCHFR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005258
• Synonyms: GFRP; HsT16933; P35
• Summary: 'GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]'