Human BMP9 (GDF2) activation kit by CRISPRa

CAT#: GA101774

GDF2 CRISPRa kit - CRISPR gene activation of human growth differentiation factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GDF2
• Locus ID: 2658
• Kit Components:

  GA101774G1, BMP9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101774G2, BMP9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101774G3, BMP9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016204
• Synonyms: BMP-9; BMP9; HHT5
• Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]'