Human GFI1 activation kit by CRISPRa

CAT#: GA101784

GFI1 CRISPRa kit - CRISPR gene activation of human growth factor independent 1 transcriptional repressor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GFI1
• Locus ID: 2672
• Kit Components:

  GA101784G1, GFI1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101784G2, GFI1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101784G3, GFI1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127215, NM_001127216, NM_005263
• Synonyms: GFI-1; GFI1A; SCN2; ZNF163
• Summary: 'This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]'