Human GH2 activation kit by CRISPRa

CAT#: GA101795

GH2 CRISPRa kit - CRISPR gene activation of human growth hormone 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GH2
• Locus ID: 2689
• Kit Components:

  GA101795G1, GH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101795G2, GH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101795G3, GH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NG_001334, NM_002059, NM_022556, NM_022557, NM_022558
• Synonyms: GH-V; GHL; GHV; hGH-V
• Summary: 'The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]'