Human Glutaredoxin 1 (GLRX) activation kit by CRISPRa

CAT#: GA101832

GLRX CRISPRa kit - CRISPR gene activation of human glutaredoxin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLRX
• Locus ID: 2745
• Kit Components:

  GA101832G1, Glutaredoxin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101832G2, Glutaredoxin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101832G3, Glutaredoxin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001118890, NM_001243658, NM_001243659, NM_002064
• Synonyms: GRX; GRX1
• Summary: 'This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]'