Human GRB10 activation kit by CRISPRa

CAT#: GA101943

GRB10 CRISPRa kit - CRISPR gene activation of human growth factor receptor bound protein 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRB10
• Locus ID: 2887
• Kit Components:

  GA101943G1, GRB10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101943G2, GRB10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101943G3, GRB10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001549, NM_001001550, NM_001001555, NM_005311, NM_001350814, NM_001350815, NM_001350816
• Synonyms: Grb-10; GRB-IR; IRBP; MEG1; RSS
• Summary: 'The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]'