Human GRF2 (RAPGEF1) activation kit by CRISPRa

CAT#: GA101945

RAPGEF1 CRISPRa kit - CRISPR gene activation of human Rap guanine nucleotide exchange factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAPGEF1
• Locus ID: 2889
• Kit Components:

  GA101945G1, GRF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101945G2, GRF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101945G3, GRF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304275, NM_005312, NM_198679
• Synonyms: C3G; GRF2
• Summary: 'This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]'