Human Glutathione Reductase (GSR) activation kit by CRISPRa

CAT#: GA101986

GSR CRISPRa kit - CRISPR gene activation of human glutathione-disulfide reductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GSR
• Locus ID: 2936
• Kit Components:

  GA101986G1, Glutathione Reductase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101986G2, Glutathione Reductase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101986G3, Glutathione Reductase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000637, NM_001195102, NM_001195103, NM_001195104
• Synonyms: HEL-75
• Summary: 'This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]'