Human Heparin Cofactor II (SERPIND1) activation kit by CRISPRa

CAT#: GA102080

SERPIND1 CRISPRa kit - CRISPR gene activation of human serpin family D member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPIND1
• Locus ID: 3053
• Kit Components:

  GA102080G1, Heparin Cofactor II gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102080G2, Heparin Cofactor II gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102080G3, Heparin Cofactor II gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000185
• Synonyms: D22S673; HC2; HCF2; HCII; HLS2; LS2; THPH10
• Summary: 'This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]'