Human HCK activation kit by CRISPRa

CAT#: GA102082

HCK CRISPRa kit - CRISPR gene activation of human HCK proto-oncogene, Src family tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HCK
• Locus ID: 3055
• Kit Components:

  GA102082G1, HCK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102082G2, HCK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102082G3, HCK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172129, NM_001172130, NM_001172131, NM_001172132, NM_001172133, NM_002110
• Synonyms: JTK9; p59Hck; p61Hck
• Summary: 'The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]'