Human HIP2 (UBE2K) activation kit by CRISPRa

CAT#: GA102109

UBE2K CRISPRa kit - CRISPR gene activation of human ubiquitin conjugating enzyme E2 K

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBE2K
• Locus ID: 3093
• Kit Components:

  GA102109G1, HIP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102109G2, HIP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102109G3, HIP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111112, NM_001111113, NM_001312646, NM_001312647, NM_001312648, NM_005339
• Synonyms: E2-25K; HIP2; HYPG; LIG; UBC1
• Summary: 'The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]'