Human HINT1 activation kit by CRISPRa

CAT#: GA102110

HINT1 CRISPRa kit - CRISPR gene activation of human histidine triad nucleotide binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HINT1
• Locus ID: 3094
• Kit Components:

  GA102110G1, HINT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102110G2, HINT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102110G3, HINT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005340, NR_024610, NR_024611, NR_073488, NR_134494, NR_134495
• Synonyms: HINT; NMAN; PKCI-1; PRKCNH1
• Summary: 'This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]'