Human Hexokinase II (HK2) activation kit by CRISPRa

CAT#: GA102114

HK2 CRISPRa kit - CRISPR gene activation of human hexokinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HK2
• Locus ID: 3099
• Kit Components:

  GA102114G1, Hexokinase II gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102114G2, Hexokinase II gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102114G3, Hexokinase II gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000189
• Synonyms: HKII; HXK2
• Summary: 'Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]'