Human HPRT (HPRT1) activation kit by CRISPRa

CAT#: GA102228

HPRT1 CRISPRa kit - CRISPR gene activation of human hypoxanthine phosphoribosyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HPRT1
• Locus ID: 3251
• Kit Components:

  GA102228G1, HPRT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102228G2, HPRT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102228G3, HPRT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000194
• Synonyms: HGPRT; HPRT
• Summary: 'The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]'