Human PRMT1 activation kit by CRISPRa

CAT#: GA102240

PRMT1 CRISPRa kit - CRISPR gene activation of human protein arginine methyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRMT1
• Locus ID: 3276
• Kit Components:

  GA102240G1, PRMT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102240G2, PRMT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102240G3, PRMT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001207042, NM_001536, NM_198318, NM_198319, NR_033397
• Synonyms: ANM1; HCP1; HRMT1L2; IR1B4
• Summary: 'This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]'