Human IL7R alpha (IL7R) activation kit by CRISPRa

CAT#: GA102390

IL7R CRISPRa kit - CRISPR gene activation of human interleukin 7 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL7R
• Locus ID: 3575
• Kit Components:

  GA102390G1, IL7R alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102390G2, IL7R alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102390G3, IL7R alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002185, NR_120485
• Synonyms: CD127; CDW127; IL-7R-alpha; IL7RA; ILRA
• Summary: 'The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]'