Human IRF6 activation kit by CRISPRa

CAT#: GA102457

IRF6 CRISPRa kit - CRISPR gene activation of human interferon regulatory factor 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRF6
• Locus ID: 3664
• Kit Components:

  GA102457G1, IRF6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102457G2, IRF6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102457G3, IRF6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206696, NM_006147
• Synonyms: LPS; OFC6; PIT; PPS; PPS1; VWS; VWS1
• Summary: 'This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]'