Human KCNJ1 activation kit by CRISPRa

CAT#: GA102534

KCNJ1 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily J member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNJ1
• Locus ID: 3758
• Kit Components:

  GA102534G1, KCNJ1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102534G2, KCNJ1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102534G3, KCNJ1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000220, NM_153764, NM_153765, NM_153766, NM_153767
• Synonyms: KIR1.1; ROMK; ROMK1
• Summary: 'Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'