Human KIR2.3 (KCNJ4) activation kit by CRISPRa

CAT#: GA102537

KCNJ4 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily J member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNJ4
• Locus ID: 3761
• Kit Components:

  GA102537G1, KIR2.3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102537G2, KIR2.3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102537G3, KIR2.3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004981, NM_152868
• Synonyms: HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3
• Summary: 'Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'