Human Plasma Kallikrein 1B (KLKB1) activation kit by CRISPRa

CAT#: GA102588

KLKB1 CRISPRa kit - CRISPR gene activation of human kallikrein B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLKB1
• Locus ID: 3818
• Kit Components:

  GA102588G1, Plasma Kallikrein 1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102588G2, Plasma Kallikrein 1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102588G3, Plasma Kallikrein 1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000892, NM_001318394, NM_001318396
• Synonyms: KLK3; PPK
• Summary: 'This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]'