Human NKG2A (KLRC1) activation kit by CRISPRa

CAT#: GA102590

KLRC1 CRISPRa kit - CRISPR gene activation of human killer cell lectin like receptor C1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLRC1
• Locus ID: 3821
• Kit Components:

  GA102590G1, NKG2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102590G2, NKG2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102590G3, NKG2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304448, NM_002259, NM_007328, NM_213657, NM_213658
• Synonyms: CD159A; NKG2; NKG2A
• Summary: 'Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]'