Human SRP1 (KPNA1) activation kit by CRISPRa

CAT#: GA102600

KPNA1 CRISPRa kit - CRISPR gene activation of human karyopherin subunit alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KPNA1
• Locus ID: 3836
• Kit Components:

  GA102600G1, SRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102600G2, SRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102600G3, SRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002264, NR_026698
• Synonyms: IPOA5; NPI-1; RCH2; SRP1
• Summary: 'The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]'