Human Cytokeratin 4 (KRT4) activation kit by CRISPRa

CAT#: GA102613

KRT4 CRISPRa kit - CRISPR gene activation of human keratin 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KRT4
• Locus ID: 3851
• Kit Components:

  GA102613G1, Cytokeratin 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102613G2, Cytokeratin 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102613G3, Cytokeratin 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002272
• Synonyms: CK-4; CK4; CYK4; K4; WSN1
• Summary: 'The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]'