Human LAIR1 activation kit by CRISPRa

CAT#: GA102646

LAIR1 CRISPRa kit - CRISPR gene activation of human leukocyte associated immunoglobulin like receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LAIR1
• Locus ID: 3903
• Kit Components:

  GA102646G1, LAIR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102646G2, LAIR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102646G3, LAIR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289023, NM_001289025, NM_001289026, NM_001289027, NM_002287, NM_021706, NM_021708, NR_110279, NR_110280
• Synonyms: CD305; LAIR-1
• Summary: 'The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'