Human LAMA3 activation kit by CRISPRa

CAT#: GA102650

LAMA3 CRISPRa kit - CRISPR gene activation of human laminin subunit alpha 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LAMA3
• Locus ID: 3909
• Kit Components:

  GA102650G1, LAMA3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102650G2, LAMA3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102650G3, LAMA3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000227, NM_001127717, NM_001127718, NM_001302996, NM_198129, NR_130106
• Synonyms: BM600; E170; LAMNA; LOCS
• Summary: 'The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]'