Human LMO1 activation kit by CRISPRa

CAT#: GA102713

LMO1 CRISPRa kit - CRISPR gene activation of human LIM domain only 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LMO1
• Locus ID: 4004
• Kit Components:

  GA102713G1, LMO1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102713G2, LMO1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102713G3, LMO1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270428, NM_002315, NR_073006
• Synonyms: RBTN1; RHOM1; TTG1
• Summary: 'This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]'