Human CYP4F3 activation kit by CRISPRa

CAT#: GA102745

CYP4F3 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 4 subfamily F member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP4F3
• Locus ID: 4051
• Kit Components:

  GA102745G1, CYP4F3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA102745G2, CYP4F3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA102745G3, CYP4F3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000896, NM_001199208, NM_001199209, NM_001369696
• Synonyms: CPF3; CYP4F; LTB4H
• Summary: This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]