Human Mad (MXD1) activation kit by CRISPRa

CAT#: GA102772

MXD1 CRISPRa kit - CRISPR gene activation of human MAX dimerization protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MXD1
• Locus ID: 4084
• Kit Components:

  GA102772G1, Mad gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102772G2, Mad gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102772G3, Mad gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001202513, NM_001202514, NM_002357
• Synonyms: BHLHC58; MAD; MAD1
• Summary: 'This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]'