Human c Maf (MAF) activation kit by CRISPRa

CAT#: GA102782

MAF CRISPRa kit - CRISPR gene activation of human MAF bZIP transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAF
• Locus ID: 4094
• Kit Components:

  GA102782G1, c Maf gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102782G2, c Maf gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102782G3, c Maf gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001031804, NM_005360
• Synonyms: c-MAF; CCA4; CTRCT21
• Summary: 'The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]'