Human MEF2B (BORCS8-MEF2B) activation kit by CRISPRa

CAT#: GA102865

BORCS8-MEF2B CRISPRa kit - CRISPR gene activation of human BORCS8-MEF2B readthrough

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BORCS8-MEF2B
• Locus ID: 4207
• Kit Components:

  GA102865G1, MEF2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102865G2, MEF2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102865G3, MEF2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134794, NM_001134795, NM_005919, NR_015420, NR_027307, NR_027308
• Synonyms: FLJ32599; FLJ46391; MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B); MGC189732; MGC189763; myocyte enhancer factor 2B; RSRFR2; RSRFR2, FLJ32599, FLJ46391, MGC189732, MGC189763
• Summary: 'This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]'