Human TRIM37 activation kit by CRISPRa

CAT#: GA103039

TRIM37 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 37

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM37
• Locus ID: 4591
• Kit Components:

  GA103039G1, TRIM37 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103039G2, TRIM37 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103039G3, TRIM37 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005207, NM_015294, NM_001320987, NM_001320988, NM_001320989, NM_001320990, NM_001353082, NM_001353083, NM_001353084, NM_001353085, NM_001353086, NR_148346, NR_148347
• Synonyms: MUL; POB1; TEF3
• Summary: 'This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]'