Human MYO1E activation kit by CRISPRa

CAT#: GA103082

MYO1E CRISPRa kit - CRISPR gene activation of human myosin IE

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYO1E
• Locus ID: 4643
• Kit Components:

  GA103082G1, MYO1E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103082G2, MYO1E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103082G3, MYO1E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004998
• Synonyms: FSGS6; HuncM-IC; MYO1C
• Summary: 'This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]'