Human p95 NBS1 (NBN) activation kit by CRISPRa

CAT#: GA103114

NBN CRISPRa kit - CRISPR gene activation of human nibrin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NBN
• Locus ID: 4683
• Kit Components:

  GA103114G1, p95 NBS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103114G2, p95 NBS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103114G3, p95 NBS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024688, NM_002485
• Synonyms: AT-V1; AT-V2; ATV; ATV, NBS, NBS1, AT-V1, AT-V2, FLJ10155, MGC87362; cell cycle regulatory protein p95; FLJ10155; MGC87362; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
• Summary: 'Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]'