p95 NBS1 (NBN) Human Gene Knockout Kit (CRISPR)

CAT#: KN414682

NBN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: p95 NBS1
• Locus ID: 4683
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001024688, NM_002485
• Synonyms: AT-V1; AT-V2; ATV; ATV, NBS, NBS1, AT-V1, AT-V2, FLJ10155, MGC87362; cell cycle regulatory protein p95; FLJ10155; MGC87362; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
• Summary: 'Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]'