Human NFATC4 activation kit by CRISPRa

CAT#: GA103184

NFATC4 CRISPRa kit - CRISPR gene activation of human nuclear factor of activated T cells 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NFATC4
• Locus ID: 4776
• Kit Components:

  GA103184G1, NFATC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103184G2, NFATC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103184G3, NFATC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136022, NM_001198965, NM_001198966, NM_001198967, NM_001288802, NM_001320043, NM_004554, NM_001363681, NM_001363682
• Synonyms: NF-AT3; NF-ATC4; NFAT3
• Summary: 'This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'