Human Nucleophosmin (NPM1) activation kit by CRISPRa

CAT#: GA103253

NPM1 CRISPRa kit - CRISPR gene activation of human nucleophosmin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPM1
• Locus ID: 4869
• Kit Components:

  GA103253G1, Nucleophosmin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103253G2, Nucleophosmin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103253G3, Nucleophosmin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037738, NM_002520, NM_199185, NM_001355006, NM_001355007, NM_001355009, NM_001355010, NR_149149
• Synonyms: B23; NPM
• Summary: 'The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]'