Human NPTX2 activation kit by CRISPRa

CAT#: GA103262

NPTX2 CRISPRa kit - CRISPR gene activation of human neuronal pentraxin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPTX2
• Locus ID: 4885
• Kit Components:

  GA103262G1, NPTX2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103262G2, NPTX2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103262G3, NPTX2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002523
• Synonyms: NARP; NP-II; NP2
• Summary: 'This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]'