Human PAR4 (PAWR) activation kit by CRISPRa

CAT#: GA103388

PAWR CRISPRa kit - CRISPR gene activation of human pro-apoptotic WT1 regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAWR
• Locus ID: 5074
• Kit Components:

  GA103388G1, PAWR gRNA vector 1 in pCas-Guide-CRISPRa

  GA103388G2, PAWR gRNA vector 2 in pCas-Guide-CRISPRa

  GA103388G3, PAWR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002583, NM_001354732, NM_001354733
• Synonyms: Par-4; PAR4
• Summary: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]