Human PDK2 activation kit by CRISPRa

CAT#: GA103461

PDK2 CRISPRa kit - CRISPR gene activation of human pyruvate dehydrogenase kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDK2
• Locus ID: 5164
• Kit Components:

  GA103461G1, PDK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103461G2, PDK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103461G3, PDK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199898, NM_001199899, NM_001199900, NM_002611
• Synonyms: PDHK2; PDKII
• Summary: 'This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]'