Human Plakophilin 2 (PKP2) activation kit by CRISPRa

CAT#: GA103579

PKP2 CRISPRa kit - CRISPR gene activation of human plakophilin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PKP2
• Locus ID: 5318
• Kit Components:

  GA103579G1, Plakophilin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103579G2, Plakophilin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103579G3, Plakophilin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005242, NM_004572
• Synonyms: ARVD9
• Summary: 'This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]'