Human PMM2 activation kit by CRISPRa

CAT#: GA103628

PMM2 CRISPRa kit - CRISPR gene activation of human phosphomannomutase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PMM2
• Locus ID: 5373
• Kit Components:

  GA103628G1, PMM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103628G2, PMM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103628G3, PMM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000303
• Synonyms: CDG1; CDG1a; CDGS; PMI; PMI1; PMM 2
• Summary: 'The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]'