Human PMP22 activation kit by CRISPRa

CAT#: GA103630

PMP22 CRISPRa kit - CRISPR gene activation of human peripheral myelin protein 22

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PMP22
• Locus ID: 5376
• Kit Components:

  GA103630G1, PMP22 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103630G2, PMP22 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103630G3, PMP22 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000304, NM_001281455, NM_001281456, NM_001330143, NM_153321, NM_153322, NR_104017, NR_104018
• Synonyms: CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; Sp110
• Summary: 'This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]'