Human PPAR delta (PPARD) activation kit by CRISPRa

CAT#: GA103687

PPARD CRISPRa kit - CRISPR gene activation of human peroxisome proliferator activated receptor delta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPARD
• Locus ID: 5467
• Kit Components:

  GA103687G1, PPAR delta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103687G2, PPAR delta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103687G3, PPAR delta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171818, NM_001171819, NM_001171820, NM_006238, NM_177435
• Synonyms: FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB
• Summary: 'This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]'