Human NIPP1 (PPP1R8) activation kit by CRISPRa

CAT#: GA103713

PPP1R8 CRISPRa kit - CRISPR gene activation of human protein phosphatase 1 regulatory subunit 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPP1R8
• Locus ID: 5511
• Kit Components:

  GA103713G1, NIPP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103713G2, NIPP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103713G3, NIPP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002713, NM_014110, NM_138558
• Synonyms: ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
• Summary: 'This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]'