Human PTP kappa (PTPRK) activation kit by CRISPRa

CAT#: GA103940

PTPRK CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type K

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPRK
• Locus ID: 5796
• Kit Components:

  GA103940G1, PTP kappa gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103940G2, PTP kappa gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103940G3, PTP kappa gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135648, NM_001291981, NM_001291982, NM_001291983, NM_001291984, NM_002844
• Synonyms: R-PTP-kappa
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]'