Human PTS activation kit by CRISPRa

CAT#: GA103949

PTS CRISPRa kit - CRISPR gene activation of human 6-pyruvoyltetrahydropterin synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTS
• Locus ID: 5805
• Kit Components:

  GA103949G1, PTS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103949G2, PTS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103949G3, PTS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000317
• Synonyms: PTPS
• Summary: 'The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]'