Human PEX19 activation kit by CRISPRa

CAT#: GA103959

PEX19 CRISPRa kit - CRISPR gene activation of human peroxisomal biogenesis factor 19

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PEX19
• Locus ID: 5824
• Kit Components:

  GA103959G1, PEX19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103959G2, PEX19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103959G3, PEX19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001131039, NM_001193644, NM_002857, NR_036492, NR_036493
• Synonyms: D1S2223E; FLJ55296; HK33; housekeeping gene, 33kD; OTTHUMP00000031848; peroxisomal biogenesis factor 19; peroxisomal farnesylated protein; PMP1; PMPI; PXF; PXMP1
• Summary: 'This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]'